Age Reversal Technologies
Cellular reprogramming, senolytics, stem cell therapy, gene therapy, and other interventions being studied as longevity technologies. Evidence levels tracked.
Age reversal technologies are interventions designed to slow, stop, or reverse biological aging at the cellular and molecular level. The field ranges from compounds in early laboratory research to therapies in human clinical trials. This hub tracks each technology's research status, evidence level, and where the science currently stands.
Cellular Reprogramming
Using transcription factors (Yamanaka factors) to partially or fully reset a cell's epigenetic age. Shows strong results in animal studies. Human safety data is very limited.
Senolytics
Drugs or compounds that selectively clear senescent cells that accumulate with aging and drive inflammation. Early human trials show safety and some biomarker effects.
Stem Cell Therapy
Deploying stem cells or cell-derived factors to regenerate damaged tissue or restore declining cell populations. Highly indication-specific -- some uses are clinically established, longevity applications are investigational.
Gene Therapy
Modifying gene expression related to longevity pathways such as telomere maintenance, DNA repair, or mTOR signaling. Some early human self-experiments; no established longevity protocols.